Chitosan films and chitosan/pectin polyelectrolyte complexes encapsulating silver sulfadiazine for wound healing

Sulfadiazine—Chitosan Conjugates and Their Polyelectrolyte Complexes with Hyaluronate Destined to the Management of Burn Wounds

In the present study polyelectrolyte complexes (PECs) based on new sulfadiazine-chitosan conjugates with sodium hyaluronate have been developed with potential use in treatment of burn wounds. The PECs were chemically characterized using Fourier Transform-Infrared Spectroscopy, Scanning Electon Microscopy and Near Infrared Chemical Imaging Technique. The swelling behavior and in vitro sulfadiazi...

Comparison between the Effect of Silymarin and Silver Sulfadiazine on Burned Wound Healing in Rats

A burn is an injury caused by transfer of thermal energy into tissue resulting in disruption of its normal anatomical structure. An experiment was carried out to compare the effect of silymarin and silver sulfadiazine on burned wound healing in rat. In this study, 36 Wistar rats were divided into 6 groups. A burn was generated on the backs of all rats by brass probe. The burned areas in the fir...

Chitosan-based polyelectrolyte complexes for drug delivery

Among different polymers, chitosan, the N-deacetylated product of the polysaccharide chitin, is gaining increasing importance in medical and pharmaceutical applications due to its good mucoadhesion and absorption enhancing ability. Moreover, chitosan shows the ability to form hydrogels able to control the rate of drug release from the delivery system as well as protect the drug from chemical an...

Preparation of tissue-engineered wound dressing consisting of chitosan fibers containing silver ion-doped bioactive nanoparticles for wound healing

Background: Wound healing is a complicated process involving the proliferation of the epithelial cells, deposition of granulation tissue as well as recruitment of inflammatory cells. It also is a hot topic of research for trauma, orthopedics and general surgery studies. There are many forms of cells involved in this process. This study aimed to design a tissue-engineered wound dressing consisti...

comparison of placenta membrane and silver sulfadiazine effect in partial thickness burn wound healing in rat